Cargando…

UBE2T promotes breast cancer tumor growth by suppressing DNA replication stress

Breast cancer is a leading cause of cancer-related deaths among women, and current therapies benefit only a subset of these patients. Here, we show that ubiquitin-conjugating enzyme E2T (UBE2T) is overexpressed in patient-derived breast cancer samples, and UBE2T overexpression predicts poor prognosi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dutta, Roshan, Guruvaiah, Praveen, Reddi, Kiran Kumar, Bugide, Suresh, Reddy Bandi, Dhana Sekhar, Edwards, Yvonne J K, Singh, Kamaljeet, Gupta, Romi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Cancer Gene Regulation, Chromatin, and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9629447/ https://www.ncbi.nlm.nih.gov/pubmed/36338541 http://dx.doi.org/10.1093/narcan/zcac035

Ejemplares similares

The human telomeric proteome during telomere replication
por: Lin, Chih-Yi Gabriela, et al.
Publicado: (2021)

Recognition and potential mechanisms for replication and erasure of cytosine hydroxymethylation
por: Hashimoto, Hideharu, et al.
Publicado: (2012)

Chromatin architectures at fission yeast transcriptional promoters and replication origins
por: Givens, Robert M., et al.
Publicado: (2012)

KAP1 facilitates reinstatement of heterochromatin after DNA replication
por: Jang, Suk Min, et al.
Publicado: (2018)

ATXN3 controls DNA replication and transcription by regulating chromatin structure
por: Hernández‐Carralero, Esperanza, et al.
Publicado: (2023)

3D chromatin conformation correlates with replication timing and is conserved in resting cells
por: Moindrot, Benoit, et al.
Publicado: (2012)

Genome conformation capture reveals that the Escherichia coli chromosome is organized by replication and transcription
por: Cagliero, Cedric, et al.
Publicado: (2013)

Replication-guided nucleosome packing and nucleosome breathing expedite the formation of dense arrays
por: Osberg, Brendan, et al.
Publicado: (2014)

Identification of multiple roles for histone acetyltransferase 1 in replication-coupled chromatin assembly
por: Agudelo Garcia, Paula A., et al.
Publicado: (2017)

Genome-wide function of MCM-BP in Trypanosoma brucei DNA replication and transcription
por: Kim, Hee-Sook
Publicado: (2019)

Replication-independent nucleosome exchange is enhanced by local and specific acetylation of histone H4
por: Elliott, Giles O., et al.
Publicado: (2013)

The replication initiator of the cholera pathogen's second chromosome shows structural similarity to plasmid initiators
por: Orlova, Natalia, et al.
Publicado: (2017)

IncC helper dependent plasmid-like replication of Salmonella Genomic Island 1
por: Szabó, Mónika, et al.
Publicado: (2021)

Cryptic transcripts from a ubiquitous plasmid origin of replication confound tests for cis-regulatory function
por: Lemp, Nathan A., et al.
Publicado: (2012)

Identification of a large protein network involved in epigenetic transmission in replicating DNA of embryonic stem cells
por: Aranda, Sergi, et al.
Publicado: (2014)

A subset of replication-dependent histone mRNAs are expressed as polyadenylated RNAs in terminally differentiated tissues
por: Lyons, Shawn M., et al.
Publicado: (2016)

Release of promoter–proximal paused Pol II in response to histone deacetylase inhibition
por: Vaid, Roshan, et al.
Publicado: (2020)

Transcription profiling during the cell cycle shows that a subset of Polycomb-targeted genes is upregulated during DNA replication
por: Peña-Diaz, Javier, et al.
Publicado: (2013)

Establishment of a promoter-based chromatin architecture on recently replicated DNA can accommodate variable inter-nucleosome spacing
por: Fennessy, Ross T., et al.
Publicado: (2016)

Temporal association of ORCA/LRWD1 to late-firing origins during G1 dictates heterochromatin replication and organization
por: Wang, Yating, et al.
Publicado: (2017)

A DNA binding winged helix domain in CAF-1 functions with PCNA to stabilize CAF-1 at replication forks
por: Zhang, Kuo, et al.
Publicado: (2016)

Repair of cisplatin-induced DNA interstrand crosslinks by a replication-independent pathway involving transcription-coupled repair and translesion synthesis
por: Enoiu, Milica, et al.
Publicado: (2012)

CDK2-dependent phosphorylation of Suv39H1 is involved in control of heterochromatin replication during cell cycle progression
por: Park, Su Hyung, et al.
Publicado: (2014)

Increasing the complexity of chromatin: functionally distinct roles for replication-dependent histone H2A isoforms in cell proliferation and carcinogenesis
por: Singh, Rajbir, et al.
Publicado: (2013)

Reduced cohesin destabilizes high-level gene amplification by disrupting pre-replication complex bindings in human cancers with chromosomal instability
por: Yun, Jiyeon, et al.
Publicado: (2016)

Methylation of histone H4 lysine 20 by PR-Set7 ensures the integrity of late replicating sequence domains in Drosophila
por: Li, Yulong, et al.
Publicado: (2016)

Body temperature variation controls pre-mRNA processing and transcription of antiviral genes and SARS-CoV-2 replication
por: Los, Bruna, et al.
Publicado: (2022)

Cellular heat shock factor 1 positively regulates human immunodeficiency virus-1 gene expression and replication by two distinct pathways
por: Rawat, Pratima, et al.
Publicado: (2011)

FUS/TLS contributes to replication-dependent histone gene expression by interaction with U7 snRNPs and histone-specific transcription factors
por: Raczynska, Katarzyna Dorota, et al.
Publicado: (2015)

H3K9me3 demethylase Kdm4d facilitates the formation of pre-initiative complex and regulates DNA replication
por: Wu, Rentian, et al.
Publicado: (2017)

LncRNA Hmrhl regulates expression of cancer related genes in chronic myelogenous leukemia through chromatin association
por: Choudhury, Subhendu Roy, et al.
Publicado: (2021)

Hyperactive Cdc2 kinase interferes with the response to broken replication forks by trapping S.pombe Crb2 in its mitotic T215 phosphorylated state
por: Mahyous Saeyd, Salah Adam, et al.
Publicado: (2014)

H3K4me3 demethylation by the histone demethylase KDM5C/JARID1C promotes DNA replication origin firing
por: Rondinelli, Beatrice, et al.
Publicado: (2015)

HSP70 binding protein 1 (HspBP1) suppresses HIV-1 replication by inhibiting NF-κB mediated activation of viral gene expression
por: Chaudhary, Priyanka, et al.
Publicado: (2016)

Functional interpretation of genetic variants using deep learning predicts impact on chromatin accessibility and histone modification
por: Hoffman, Gabriel E, et al.
Publicado: (2019)

Modeling complex patterns of differential DNA methylation that associate with gene expression changes
por: Schlosberg, Christopher E., et al.
Publicado: (2017)

H3K4me2 and WDR5 enriched chromatin interacting long non-coding RNAs maintain transcriptionally competent chromatin at divergent transcriptional units
por: Subhash, Santhilal, et al.
Publicado: (2018)

DNA recognition by Escherichia coli CbpA protein requires a conserved arginine–minor-groove interaction
por: Chintakayala, Kiran, et al.
Publicado: (2015)

Common and divergent features in transcriptional control of the homologous small RNAs GlmY and GlmZ in Enterobacteriaceae
por: Göpel, Yvonne, et al.
Publicado: (2011)

Efficient programmable gene silencing by Cascade
por: Rath, Devashish, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_2j5a2aj8iq5dt1mk9h2ciqfbqf