Kinetic frustration by limited bond availability controls the LAT protein condensation phase transition on membranes

LAT is a membrane-linked scaffold protein that undergoes a phase transition to form a two-dimensional protein condensate on the membrane during T cell activation. Governed by tyrosine phosphorylation, LAT recruits various proteins that ultimately enable condensation through a percolation network of...

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Detalles Bibliográficos
Autores principales: Sun, Simou, GrandPre, Trevor, Limmer, David T., Groves, Jay T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Physical and Materials Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9629719/
https://www.ncbi.nlm.nih.gov/pubmed/36322659
http://dx.doi.org/10.1126/sciadv.abo5295

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9629719/
https://www.ncbi.nlm.nih.gov/pubmed/36322659
http://dx.doi.org/10.1126/sciadv.abo5295

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