Single-cell multiomics identifies clinically relevant mesenchymal stem-like cells and key regulators for MPNST malignancy

Malignant peripheral nerve sheath tumor (MPNST), a highly aggressive Schwann cell (SC)–derived soft tissue sarcoma, arises from benign neurofibroma (NF); however, the identity, heterogeneity and origins of tumor populations remain elusive. Nestin(+) cells have been implicated as tumor stem cells in...

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Detalles Bibliográficos
Autores principales: Wu, Lai Man Natalie, Zhang, Feng, Rao, Rohit, Adam, Mike, Pollard, Kai, Szabo, Sara, Liu, Xuezhao, Belcher, Katie A., Luo, Zaili, Ogurek, Sean, Reilly, Colleen, Zhou, Xin, Zhang, Li, Rubin, Joshua, Chang, Long-sheng, Xin, Mei, Yu, Jiyang, Suva, Mario, Pratilas, Christine A., Potter, Steven, Lu, Q. Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9629745/
https://www.ncbi.nlm.nih.gov/pubmed/36322658
http://dx.doi.org/10.1126/sciadv.abo5442

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9629745/
https://www.ncbi.nlm.nih.gov/pubmed/36322658
http://dx.doi.org/10.1126/sciadv.abo5442

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