Tanshinone functions as a coenzyme that confers gain of function of NQO1 to suppress ferroptosis

Ferroptosis is triggered by the breakdown of cellular iron-dependent redox homeostasis and the abnormal accumulation of lipid ROS. Cells have evolved defense mechanisms to prevent lipid ROS accumulation and ferroptosis. Using a library of more than 4,000 bioactive compounds, we show that tanshinone...

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Detalles Bibliográficos
Autores principales: Wang, Tian-Xiang, Duan, Kun-Long, Huang, Zi-Xuan, Xue, Zi-An, Liang, Jun-Yun, Dang, Yongjun, Zhang, Ao, Xiong, Yue, Ding, Chunyong, Guan, Kun-Liang, Yuan, Hai-Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9629850/
https://www.ncbi.nlm.nih.gov/pubmed/36319062
http://dx.doi.org/10.26508/lsa.202201667

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9629850/
https://www.ncbi.nlm.nih.gov/pubmed/36319062
http://dx.doi.org/10.26508/lsa.202201667

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