Development of ASIC1a ligand-gated ion channel drug screening assays across multiple automated patch clamp platforms

Human acid-sensing ion channels (ASIC) are ligand-gated ionotropic receptors expressed widely in peripheral tissues as well as sensory and central neurons and implicated in detection of inflammation, tissue injury, and hypoxia-induced acidosis. This makes ASIC channels promising targets for drug dis...

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Detalles Bibliográficos
Autores principales: Ridley, John, Manyweathers, Sam, Tang, Raymond, Goetze, Tom, Becker, Nadine, Rinke-Weiß, Ilka, Kirby, Robert, Obergrussberger, Alison, Rogers, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9629855/
https://www.ncbi.nlm.nih.gov/pubmed/36340694
http://dx.doi.org/10.3389/fnmol.2022.982689

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9629855/
https://www.ncbi.nlm.nih.gov/pubmed/36340694
http://dx.doi.org/10.3389/fnmol.2022.982689

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