Determination of Anti-drug Antibody Affinity in Clinical Study Samples Provides a Tool for Evaluation of Immune Response Maturation

Characterization of clinical anti-drug antibody (ADA) responses to biotherapeutics can be important to understanding the consequences of immunogenicity. ADA are expected to be polyclonal, with composition and affinities that evolve over time. Measuring ADA binding affinity can be complicated by the...

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Detalles Bibliográficos
Autores principales: Joyce, Alison, Shea, Christopher, You, Zhiping, Gorovits, Boris, Lepsy, Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9629885/
https://www.ncbi.nlm.nih.gov/pubmed/36324032
http://dx.doi.org/10.1208/s12248-022-00759-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9629885/
https://www.ncbi.nlm.nih.gov/pubmed/36324032
http://dx.doi.org/10.1208/s12248-022-00759-1

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