Cargando…

Targeting epiregulin in the treatment-damaged tumor microenvironment restrains therapeutic resistance

The tumor microenvironment (TME) represents a milieu enabling cancer cells to develop malignant properties, while concerted interactions between cancer and stromal cells frequently shape an “activated/reprogramed” niche to accelerate pathological progression. Here we report that a soluble factor epi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Changxu, Long, Qilai, Fu, Qiang, Xu, Qixia, Fu, Da, Li, Yan, Gao, Libin, Guo, Jianming, Zhang, Xiaoling, Lam, Eric W.-F., Campisi, Judith, Sun, Yu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630100/ https://www.ncbi.nlm.nih.gov/pubmed/36202915 http://dx.doi.org/10.1038/s41388-022-02476-7

Ejemplares similares

Targeting SPINK1 in the damaged tumour microenvironment alleviates therapeutic resistance
por: Chen, Fei, et al.
Publicado: (2018)

Stress-Induced Neuroprotective Effects of Epiregulin and Amphiregulin
por: Zhan, Libin, et al.
Publicado: (2015)

PDK4-dependent hypercatabolism and lactate production of senescent cells promotes cancer malignancy
por: Dou, Xuefeng, et al.
Publicado: (2023)

Targeting amphiregulin (AREG) derived from senescent stromal cells diminishes cancer resistance and averts programmed cell death 1 ligand (PD‐L1)‐mediated immunosuppression
por: Xu, Qixia, et al.
Publicado: (2019)

Epiregulin as a therapeutic target in non-small-cell lung cancer
por: Sunaga, Noriaki, et al.
Publicado: (2015)

Epiregulin Promotes Lung Metastasis of Salivary Adenoid Cystic Carcinoma
por: Yang, Wen-Wen, et al.
Publicado: (2017)

Epiregulin expression and secretion is increased in castration-resistant prostate cancer
por: Wiesehöfer, Marc, et al.
Publicado: (2023)

OGT restrains the expansion of DNA damage signaling
por: Chen, Qiang, et al.
Publicado: (2016)

Cholesteatoma Fibroblasts Promote Epithelial Cell Proliferation through Overexpression of Epiregulin
por: Yoshikawa, Mamoru, et al.
Publicado: (2013)

Epiregulin is released from intervertebral disks and induces spontaneous activity in pain pathways
por: Kongstorp, Mette, et al.
Publicado: (2019)

EPIREGULIN creates a developmental niche for spatially organized human intestinal enteroids
por: Childs, Charlie J., et al.
Publicado: (2023)

Epiregulin increases stemness-associated genes expression and promotes chemoresistance of non-small cell lung cancer via ERK signaling
por: Zhang, Yujia, et al.
Publicado: (2022)

Epiregulin, epigen and betacellulin antibodies and axial elongation in young guinea pigs with lens-induced myopization
por: Dong, Li, et al.
Publicado: (2022)

Amphiregulin and Epiregulin mRNA expression in primary colorectal cancer and corresponding liver metastases
por: Kuramochi, Hidekazu, et al.
Publicado: (2012)

Evidence that TSC2 acts as a transcription factor and binds to and represses the promoter of Epiregulin
por: Pradhan, Shalmali Avinash, et al.
Publicado: (2014)

Prognostic value of amphiregulin and epiregulin mRNA expression in metastatic colorectal cancer patients
por: Jing, Chen, et al.
Publicado: (2016)

Epiregulin as an Alternative Ligand for Leptin Receptor Alleviates Glucose Intolerance without Change in Obesity
por: Song, No-Joon, et al.
Publicado: (2022)

Epiregulin gene expression as a biomarker of benefit from cetuximab in the treatment of advanced colorectal cancer
por: Jonker, D J, et al.
Publicado: (2014)

Epiregulin contributes to breast tumorigenesis through regulating matrix metalloproteinase 1 and promoting cell survival
por: Farooqui, Mariya, et al.
Publicado: (2015)

Rab27b contributes to radioresistance and exerts a paracrine effect via epiregulin in glioblastoma
por: Nishioka, Soichiro, et al.
Publicado: (2020)

Autocrine epiregulin activates EGFR pathway for lung metastasis via EMT in salivary adenoid cystic carcinoma
por: Liu, Shuli, et al.
Publicado: (2016)

Epiregulin enhances odontoblastic differentiation of dental pulp stem cells via activating MAPK signalling pathway
por: Cui, Dixin, et al.
Publicado: (2019)

Checkpoint molecules coordinately restrain hyperactivated effector T cells in the tumor microenvironment
por: Yang, Min, et al.
Publicado: (2020)

Revisiting ovarian cancer microenvironment: a friend or a foe?
por: Zhang, Boyi, et al.
Publicado: (2017)

Remodeling and Restraining Lung Tissue Damage Through the Regulation of Respiratory Immune Responses
por: Pyung, Young Jin, et al.
Publicado: (2023)

The effect of epiregulin on epidermal growth factor receptor expression and proliferation of oral squamous cell carcinoma cell lines
por: Kong, Darren Chyi-Hsiang, et al.
Publicado: (2014)

Intermittent hypoxia‐induced epiregulin expression by IL‐6 production in human coronary artery smooth muscle cells
por: Kyotani, Yoji, et al.
Publicado: (2018)

Epiregulin promotes hair growth via EGFR‐medicated epidermal and ErbB4‐mediated dermal stimulation
por: Choi, Nahyun, et al.
Publicado: (2020)

Downregulation of HBx Restrains Proliferation, Migration, and Invasion of HepG2 Cells
por: Huang, Chaoqun, et al.
Publicado: (2021)

Multisite SUMOylation restrains DNA polymerase η interactions with DNA damage sites
por: Guérillon, Claire, et al.
Publicado: (2020)

The PDE4 Inhibitor Tanimilast Restrains the Tissue-Damaging Properties of Human Neutrophils
por: Schioppa, Tiziana, et al.
Publicado: (2022)

The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice
por: Xu, Qixia, et al.
Publicado: (2021)

Epiregulin reprograms cancer-associated fibroblasts and facilitates oral squamous cell carcinoma invasion via JAK2-STAT3 pathway
por: Wang, Yujia, et al.
Publicado: (2019)

Epiregulin promotes trophoblast epithelial–mesenchymal transition through poFUT1 and O‐fucosylation by poFUT1 on uPA
por: Cui, Xinyuan, et al.
Publicado: (2019)

Pharmacologic Inhibition of SHP2 Blocks Both PI3K and MEK Signaling in Low-epiregulin HNSCC via GAB1
por: Kurupi, Richard, et al.
Publicado: (2022)

Competing endogenous network analysis identifies lncRNA Meg3 activates inflammatory damage in UVB induced murine skin lesion by sponging miR-93-5p/epiregulin axis
por: Zhang, Nan, et al.
Publicado: (2019)

GEMMI and Servalcat restrain REFMAC5
por: Yamashita, Keitaro, et al.
Publicado: (2023)

Proteins in the Nutrient-Sensing and DNA Damage Checkpoint Pathways Cooperate to Restrain Mitotic Progression following DNA Damage
por: Searle, Jennifer S., et al.
Publicado: (2011)

Targeting HIC1/TGF-β axis-shaped prostate cancer microenvironment restrains its progression
por: Wu, Tianqi, et al.
Publicado: (2022)

Serum levels of hepatocyte growth factor and epiregulin are associated with the prognosis on anti-EGFR antibody treatment in KRAS wild-type metastatic colorectal cancer
por: Takahashi, N, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_6no7uc4t1fi09bb2mcu5pi8v23