CRISPR-based kinome-screening revealed MINK1 as a druggable player to rewire 5FU-resistance in OSCC through AKT/MDM2/p53 axis

Cisplatin, 5FU and docetaxel (TPF) are the most common chemotherapy regimen used for advanced OSCC. However, many cancer patients experience relapse, continued tumor growth, and spread due to drug resistance, which leads to treatment failure and metastatic disease. Here, using a CRISPR/Cas9 based ki...

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Detalles Bibliográficos
Autores principales: Mohanty, Sibasish, Mohapatra, Pallavi, Shriwas, Omprakash, Ansari, Shamima Azma, Priyadarshini, Manashi, Priyadarsini, Swatismita, Rath, Rachna, Sultania, Mahesh, Das Majumdar, Saroj Kumar, Swain, Rajeeb K., Dash, Rupesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630125/
https://www.ncbi.nlm.nih.gov/pubmed/36182968
http://dx.doi.org/10.1038/s41388-022-02475-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630125/
https://www.ncbi.nlm.nih.gov/pubmed/36182968
http://dx.doi.org/10.1038/s41388-022-02475-8

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