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CRISPR-based kinome-screening revealed MINK1 as a druggable player to rewire 5FU-resistance in OSCC through AKT/MDM2/p53 axis
Cisplatin, 5FU and docetaxel (TPF) are the most common chemotherapy regimen used for advanced OSCC. However, many cancer patients experience relapse, continued tumor growth, and spread due to drug resistance, which leads to treatment failure and metastatic disease. Here, using a CRISPR/Cas9 based ki...
Autores principales: | Mohanty, Sibasish, Mohapatra, Pallavi, Shriwas, Omprakash, Ansari, Shamima Azma, Priyadarshini, Manashi, Priyadarsini, Swatismita, Rath, Rachna, Sultania, Mahesh, Das Majumdar, Saroj Kumar, Swain, Rajeeb K., Dash, Rupesh |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630125/ https://www.ncbi.nlm.nih.gov/pubmed/36182968 http://dx.doi.org/10.1038/s41388-022-02475-8 |
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