Enhancer decommissioning by MLL4 ablation elicits dsRNA-interferon signaling and GSDMD-mediated pyroptosis to potentiate anti-tumor immunity

Enhancer deregulation is a well-established pro-tumorigenic mechanism but whether it plays a regulatory role in tumor immunity is largely unknown. Here, we demonstrate that tumor cell ablation of mixed-lineage leukemia 3 and 4 (MLL3 and MLL4, also known as KMT2C and KMT2D, respectively), two enhance...

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Detalles Bibliográficos
Autores principales: Ning, Hanhan, Huang, Shan, Lei, Yang, Zhi, Renyong, Yan, Han, Jin, Jiaxing, Hu, Zhenyu, Guo, Kaimin, Liu, Jinhua, Yang, Jie, Liu, Zhe, Ba, Yi, Gao, Xin, Hu, Deqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630274/
https://www.ncbi.nlm.nih.gov/pubmed/36323669
http://dx.doi.org/10.1038/s41467-022-34253-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630274/
https://www.ncbi.nlm.nih.gov/pubmed/36323669
http://dx.doi.org/10.1038/s41467-022-34253-1

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