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A comprehensive Bioconductor ecosystem for the design of CRISPR guide RNAs across nucleases and technologies
The success of CRISPR-mediated gene perturbation studies is highly dependent on the quality of gRNAs, and several tools have been developed to enable optimal gRNA design. However, these tools are not all adaptable to the latest CRISPR modalities or nucleases, nor do they offer comprehensive annotati...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630310/ https://www.ncbi.nlm.nih.gov/pubmed/36323688 http://dx.doi.org/10.1038/s41467-022-34320-7 |