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Integrative molecular analyses define correlates of high B7-H3 expression in metastatic castrate-resistant prostate cancer

B7-H3 (CD276) is an immune checkpoint overexpressed in prostate cancer with minimal expression in normal tissues and associated with poor prognosis, making it an excellent therapy target. We interrogated B7-H3 expression and its regulation in metastatic castration-resistant prostate cancer (mCRPC)....

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Detalles Bibliográficos
Autores principales: Shi, Xiaolei, Day, Abderrahman, Bergom, Hannah E., Tape, Sydney, Baca, Sylvan C., Sychev, Zoi E., Larson, Gabrianne, Bozicevich, Asha, Drake, Justin M., Zorko, Nicholas, Wang, Jinhua, Ryan, Charles J., Antonarakis, Emmanuel S., Hwang, Justin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630314/
https://www.ncbi.nlm.nih.gov/pubmed/36323882
http://dx.doi.org/10.1038/s41698-022-00323-2