Direct AKT activation in tumor-infiltrating lymphocytes markedly increases interferon-γ (IFN-γ) for the regression of tumors resistant to PD-1 checkpoint blockade

PD-1 immune checkpoint blockade against inhibitory receptors such as receptor programmed cell death-1 (PD-1), has revolutionized cancer treatment. Effective immune reactivity against tumour antigens requires the infiltration and activation of tumour-infiltrating T-cells (TILs). In this context, liga...

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Detalles Bibliográficos
Autores principales: Santinon, François, Ezzahra, Bennani Fatima, Bachais, Meriem, Sarabia Pacis, Alain, Rudd, Christopher E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630443/
https://www.ncbi.nlm.nih.gov/pubmed/36323740
http://dx.doi.org/10.1038/s41598-022-23016-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630443/
https://www.ncbi.nlm.nih.gov/pubmed/36323740
http://dx.doi.org/10.1038/s41598-022-23016-z

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