Parallel functional annotation of cancer-associated missense mutations in histone methyltransferases

Using exome sequencing for biomarker discovery and precision medicine requires connecting nucleotide-level variation with functional changes in encoded proteins. However, for functionally annotating the thousands of cancer-associated missense mutations, or variants of uncertain significance (VUS), p...

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Detalles Bibliográficos
Autores principales: Canning, Ashley J., Viggiano, Susan, Fernandez-Zapico, Martin E., Cosgrove, Michael S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630446/
https://www.ncbi.nlm.nih.gov/pubmed/36323913
http://dx.doi.org/10.1038/s41598-022-23229-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630446/
https://www.ncbi.nlm.nih.gov/pubmed/36323913
http://dx.doi.org/10.1038/s41598-022-23229-2

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