Reactive astrocytes transduce inflammation in a blood-brain barrier model through a TNF-STAT3 signaling axis and secretion of alpha 1-antichymotrypsin

Astrocytes are critical components of the neurovascular unit that support blood-brain barrier (BBB) function. Pathological transformation of astrocytes to reactive states can be protective or harmful to BBB function. Here, using a human induced pluripotent stem cell (iPSC)-derived BBB co-culture mod...

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Detalles Bibliográficos
Autores principales: Kim, Hyosung, Leng, Kun, Park, Jinhee, Sorets, Alexander G., Kim, Suil, Shostak, Alena, Embalabala, Rebecca J., Mlouk, Kate, Katdare, Ketaki A., Rose, Indigo V. L., Sturgeon, Sarah M., Neal, Emma H., Ao, Yan, Wang, Shinong, Sofroniew, Michael V., Brunger, Jonathan M., McMahon, Douglas G., Schrag, Matthew S., Kampmann, Martin, Lippmann, Ethan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630454/
https://www.ncbi.nlm.nih.gov/pubmed/36323693
http://dx.doi.org/10.1038/s41467-022-34412-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630454/
https://www.ncbi.nlm.nih.gov/pubmed/36323693
http://dx.doi.org/10.1038/s41467-022-34412-4

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