Cargando…

Uncertainty-informed deep learning models enable high-confidence predictions for digital histopathology

A model’s ability to express its own predictive uncertainty is an essential attribute for maintaining clinical user confidence as computational biomarkers are deployed into real-world medical settings. In the domain of cancer digital histopathology, we describe a clinically-oriented approach to unce...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dolezal, James M., Srisuwananukorn, Andrew, Karpeyev, Dmitry, Ramesh, Siddhi, Kochanny, Sara, Cody, Brittany, Mansfield, Aaron S., Rakshit, Sagar, Bansal, Radhika, Bois, Melanie C., Bungum, Aaron O., Schulte, Jefree J., Vokes, Everett E., Garassino, Marina Chiara, Husain, Aliya N., Pearson, Alexander T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630455/ https://www.ncbi.nlm.nih.gov/pubmed/36323656 http://dx.doi.org/10.1038/s41467-022-34025-x

Ejemplares similares

Deep learning generates synthetic cancer histology for explainability and education
por: Dolezal, James M., et al.
Publicado: (2023)

AB012. Automated histologic subtyping of thymic epithelial tumors with deep learning
por: Dolezal, James M., et al.
Publicado: (2022)

Update on the pathologic diagnosis of malignant mesothelioma
por: Schulte, Jefree J., et al.
Publicado: (2020)

Application of immunohistochemistry in diagnosis and management of malignant mesothelioma
por: Chapel, David B., et al.
Publicado: (2020)

Correlation of Somatostatin Receptor 2 Expression, 68Ga-DOTATATE PET Scan and Octreotide Treatment in Thymic Epithelial Tumors
por: Roden, Anja C., et al.
Publicado: (2022)

The impact of site-specific digital histology signatures on deep learning model accuracy and bias
por: Howard, Frederick M., et al.
Publicado: (2021)

On Bayesian treatment of systematic uncertainties in confidence interval calculation
por: Tegenfeldt, Fredrik, et al.
Publicado: (2004)

Integration of clinical features and deep learning on pathology for the prediction of breast cancer recurrence assays and risk of recurrence
por: Howard, Frederick M., et al.
Publicado: (2023)

What is the ideal endpoint in early-stage immunotherapy neoadjuvant trials in lung cancer?
por: Cameron, Robert B., et al.
Publicado: (2023)

Extramedullary disease in multiple myeloma
por: Bansal, Radhika, et al.
Publicado: (2021)

Confidence through consensus: a neural mechanism for uncertainty monitoring
por: Paz, Luciano, et al.
Publicado: (2016)

Confidence in uncertainty: Error cost and commitment in early speech hypotheses
por: Loth, Sebastian, et al.
Publicado: (2018)

Uncertain About Uncertainty: How Qualitative Expressions of Forecaster Confidence Impact Decision-Making With Uncertainty Visualizations
por: Padilla, Lace M. K., et al.
Publicado: (2021)

Role of PAX8 in the regulation of MET and RON receptor tyrosine kinases in non-small cell lung cancer
por: Kanteti, Rajani, et al.
Publicado: (2014)

Exosomal miRNAs species in the blood of small cell and non-small cell lung cancer patients
por: Poroyko, Valeriy, et al.
Publicado: (2018)

Heterogeneity in PD-L1 expression in malignant peritoneal mesothelioma with systemic or intraperitoneal chemotherapy
por: White, Michael G., et al.
Publicado: (2020)

Uncertainty in Population Growth Rates: Determining Confidence Intervals from Point Estimates of Parameters
por: Devenish Nelson, Eleanor S., et al.
Publicado: (2010)

Improving confidence intervals for normed test scores: Include uncertainty due to sampling variability
por: Voncken, Lieke, et al.
Publicado: (2018)

Acknowledging Uncertainty in Economic Forecasting. Some Insight from Confidence and Industrial Trend Surveys
por: López-Menéndez, Ana Jesús, et al.
Publicado: (2019)

Contributions of anterior cingulate cortex and basolateral amygdala to decision confidence and learning under uncertainty
por: Stolyarova, A., et al.
Publicado: (2019)

A scheme to evaluate structural alerts to predict toxicity – Assessing confidence by characterising uncertainties
por: Cronin, Mark T.D., et al.
Publicado: (2022)

Development and Validation of a Decision Analytical Model for Posttreatment Surveillance for Patients With Oropharyngeal Carcinoma
por: Nair, Vivek, et al.
Publicado: (2022)

O-6-methylguanine-deoxyribonucleic acid methyltransferase methylation enhances response to temozolomide treatment in esophageal cancer
por: Hasina, Rifat, et al.
Publicado: (2013)

Differential responsiveness of MET inhibition in non-small-cell lung cancer with altered CBL
por: Tan, Yi-Hung Carol, et al.
Publicado: (2017)

Role of protein kinase C β and vascular endothelial growth factor receptor in malignant pleural mesothelioma: Therapeutic implications and the usefulness of Caenorhabditis elegans model organism
por: Loganathan, Sivakumar, et al.
Publicado: (2011)

Confidence from uncertainty - A multi-target drug screening method from robust control theory
por: Luni, Camilla, et al.
Publicado: (2010)

Development and validation of the nursing confidence in managing sedation complications scale
por: Conway, Aaron, et al.
Publicado: (2021)

The effect of disinformation about COVID-19 on consumer confidence: Insights from a survey experiment()
por: Balcaen, Pieter, et al.
Publicado: (2023)

Central lung gene expression associates with myofibroblast features in idiopathic pulmonary fibrosis
por: Huang, Yong, et al.
Publicado: (2023)

Uncertainty and Traceability for the CEESI Iowa Natural Gas Facility
por: Johnson, Aaron, et al.
Publicado: (2004)

Navigating Uncertainty: Health Professionals' Knowledge, Skill, and Confidence in Assessing and Managing Pain in Children with Profound Cognitive Impairment
por: Carter, Bernie, et al.
Publicado: (2016)

HOW CONFIDENT IS THE CONFIDENCE INTERVAL
por: Egbuchulem, K.I.
Publicado: (2022)

Duphold: scalable, depth-based annotation and curation of high-confidence structural variant calls
por: Pedersen, Brent S, et al.
Publicado: (2019)

Paradoxical Interaction between Ocular Activity, Perception, and Decision Confidence at the Threshold of Vision
por: Schurger, Aaron, et al.
Publicado: (2015)

The fallacy of placing confidence in confidence intervals
por: Morey, Richard D., et al.
Publicado: (2015)

Do confidence ratings prime confidence?
por: Double, Kit S., et al.
Publicado: (2019)

Confidence-ranked reconstruction of census microdata from published statistics
por: Dick, Travis, et al.
Publicado: (2023)

The impact of male overweight on semen quality and outcome of assisted reproduction
por: Thomsen, Lise, et al.
Publicado: (2014)

MET/PKCß expression correlate with metastasis and inhibition is synergistic in lung cancer
por: Faoro, Leonardo, et al.
Publicado: (2009)

A Residency Interview Training Program to Improve Medical Student Confidence in the Residency Interview
por: Donaldson, Katelyn, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_2r5clpff1rt4brqfc207irkpja