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Vexed mutations promote degeneration of dopaminergic neurons through excessive activation of the innate immune response

The hallmark of Parkinson’s disease (PD) is the loss of dopaminergic (DA) neurons in the brain. However, little is known about why DA neurons are selectively vulnerable to PD. We previously completed a screen identifying genes associated with the progressive degeneration of DA neurons. Here we descr...

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Detalles Bibliográficos
Autores principales: Davis, Jacinta, Kolaski, Elizabeth, Babcock, Daniel T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630459/
https://www.ncbi.nlm.nih.gov/pubmed/36323700
http://dx.doi.org/10.1038/s41531-022-00417-5