Intrabiliary infusion of naked DNA vectors targets periportal hepatocytes in mice

Hydrodynamic tail vein injection (HTV) is the “gold standard” for delivering naked DNA vectors to mouse liver, thereby transfecting predominately perivenous hepatocytes. While HTV corrects metabolic liver defects such as phenylketonuria or cystathionine β-synthase deficiency, correction of spf(ash)...

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Detalles Bibliográficos
Autores principales: Deplazes, Sereina, Schlegel, Andrea, Song, Zhuolun, Allegri, Gabriella, Rimann, Nicole, Scherer, Tanja, Willimann, Melanie, Opitz, Lennart, Cunningham, Sharon C., Alexander, Ian E., Kipar, Anja, Häberle, Johannes, Thöny, Beat, Grisch-Chan, Hiu Man
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630613/
https://www.ncbi.nlm.nih.gov/pubmed/36381301
http://dx.doi.org/10.1016/j.omtm.2022.10.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630613/
https://www.ncbi.nlm.nih.gov/pubmed/36381301
http://dx.doi.org/10.1016/j.omtm.2022.10.006

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