LPA disruption with AAV-CRISPR potently lowers plasma apo(a) in transgenic mouse model: A proof-of-concept study

Lipoprotein(a) (Lp(a)) represents a unique subclass of circulating lipoprotein particles and consists of an apolipoprotein(a) (apo(a)) molecule covalently bound to apolipoprotein B-100. The metabolism of Lp(a) particles is distinct from that of low-density lipoprotein (LDL) cholesterol, and currentl...

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Detalles Bibliográficos
Autores principales: Doerfler, Alexandria M., Park, So Hyun, Assini, Julia M., Youssef, Amer, Saxena, Lavanya, Yaseen, Adam B., De Giorgi, Marco, Chuecos, Marcel, Hurley, Ayrea E., Li, Ang, Marcovina, Santica M., Bao, Gang, Boffa, Michael B., Koschinsky, Marlys L., Lagor, William R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630778/
https://www.ncbi.nlm.nih.gov/pubmed/36381302
http://dx.doi.org/10.1016/j.omtm.2022.10.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630778/
https://www.ncbi.nlm.nih.gov/pubmed/36381302
http://dx.doi.org/10.1016/j.omtm.2022.10.009

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