Force generation of KIF1C is impaired by pathogenic mutations

Intracellular transport is essential for neuronal function and survival. The most effective plus-end-directed neuronal transporter is the kinesin-3 KIF1C, which transports large secretory vesicles and endosomes.1, 2, 3, 4 Mutations in KIF1C cause hereditary spastic paraplegia and cerebellar dysfunct...

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Detalles Bibliográficos
Autores principales: Siddiqui, Nida, Roth, Daniel, Toleikis, Algirdas, Zwetsloot, Alexander J., Cross, Robert A., Straube, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631238/
https://www.ncbi.nlm.nih.gov/pubmed/35961316
http://dx.doi.org/10.1016/j.cub.2022.07.029

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631238/
https://www.ncbi.nlm.nih.gov/pubmed/35961316
http://dx.doi.org/10.1016/j.cub.2022.07.029

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