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Force generation of KIF1C is impaired by pathogenic mutations
Intracellular transport is essential for neuronal function and survival. The most effective plus-end-directed neuronal transporter is the kinesin-3 KIF1C, which transports large secretory vesicles and endosomes.1, 2, 3, 4 Mutations in KIF1C cause hereditary spastic paraplegia and cerebellar dysfunct...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631238/ https://www.ncbi.nlm.nih.gov/pubmed/35961316 http://dx.doi.org/10.1016/j.cub.2022.07.029 |