Mitotic DNA synthesis is caused by transcription-replication conflicts in BRCA2-deficient cells

Aberrant replication causes cells lacking BRCA2 to enter mitosis with under-replicated DNA, which activates a repair mechanism known as mitotic DNA synthesis (MiDAS). Here, we identify genome-wide the sites where MiDAS reactions occur when BRCA2 is abrogated. High-resolution profiling revealed that...

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Detalles Bibliográficos
Autores principales: Groelly, Florian J., Dagg, Rebecca A., Petropoulos, Michalis, Rossetti, Giacomo G., Prasad, Birbal, Panagopoulos, Andreas, Paulsen, Teressa, Karamichali, Angeliki, Jones, Samuel E., Ochs, Fena, Dionellis, Vasilis S., Puig Lombardi, Emilia, Miossec, Matthieu J., Lockstone, Helen, Legube, Gaëlle, Blackford, Andrew N., Altmeyer, Matthias, Halazonetis, Thanos D., Tarsounas, Madalena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631240/
https://www.ncbi.nlm.nih.gov/pubmed/36002001
http://dx.doi.org/10.1016/j.molcel.2022.07.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631240/
https://www.ncbi.nlm.nih.gov/pubmed/36002001
http://dx.doi.org/10.1016/j.molcel.2022.07.011

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