Inhibition of ABL1 by tyrosine kinase inhibitors leads to a downregulation of MLH1 by Hsp70-mediated lysosomal protein degradation

The DNA mismatch repair (MMR) pathway and its regulation are critical for genomic stability. Mismatch repair (MMR) follows replication and repairs misincorporated bases and small insertions or deletions that are not recognized and removed by the proofreading polymerase. Cells deficient in MMR exhibi...

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Detalles Bibliográficos
Autores principales: Daniels, Hannah G., Knicely, Breanna G., Miller, Anna Kristin, Thompson, Ana, Plattner, Rina, Goellner, Eva M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631443/
https://www.ncbi.nlm.nih.gov/pubmed/36338985
http://dx.doi.org/10.3389/fgene.2022.940073

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631443/
https://www.ncbi.nlm.nih.gov/pubmed/36338985
http://dx.doi.org/10.3389/fgene.2022.940073

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