SARS-CoV-2 spike opening dynamics and energetics reveal the individual roles of glycans and their collective impact

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The trimeric spike (S) glycoprotein, which protrudes from the SARS-CoV-2 viral envelope, binds to human ACE2, initiated by at least one protomer’s receptor binding domain (RBD) switching from a "down” (closed) to an "up” (open) state. Here, we used large-scale molecular dynamics simulation...

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Detalles Bibliográficos
Autores principales: Pang, Yui Tik, Acharya, Atanu, Lynch, Diane L., Pavlova, Anna, Gumbart, James C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631587/
https://www.ncbi.nlm.nih.gov/pubmed/36329138
http://dx.doi.org/10.1038/s42003-022-04138-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631587/
https://www.ncbi.nlm.nih.gov/pubmed/36329138
http://dx.doi.org/10.1038/s42003-022-04138-6

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