A conformational transition of the D′D3 domain primes von Willebrand factor for multimerization

Von Willebrand factor (VWF) is a multimeric plasma glycoprotein that is critically involved in hemostasis. Biosynthesis of long VWF concatemers in the endoplasmic reticulum and the trans-Golgi is still not fully understood. We use the single-molecule force spectroscopy technique magnetic tweezers to...

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Detalles Bibliográficos
Autores principales: Gruber, Sophia, Löf, Achim, Hausch, Adina, Kutzki, Fabian, Jöhr, Res, Obser, Tobias, König, Gesa, Schneppenheim, Reinhard, Aponte-Santamaría, Camilo, Gräter, Frauke, Brehm, Maria A., Benoit, Martin, Lipfert, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2022
Materias:
Thrombosis and Hemostasis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631632/
https://www.ncbi.nlm.nih.gov/pubmed/36069828
http://dx.doi.org/10.1182/bloodadvances.2022006978

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631632/
https://www.ncbi.nlm.nih.gov/pubmed/36069828
http://dx.doi.org/10.1182/bloodadvances.2022006978

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