Cargando…

A conformational transition of the D′D3 domain primes von Willebrand factor for multimerization

Von Willebrand factor (VWF) is a multimeric plasma glycoprotein that is critically involved in hemostasis. Biosynthesis of long VWF concatemers in the endoplasmic reticulum and the trans-Golgi is still not fully understood. We use the single-molecule force spectroscopy technique magnetic tweezers to...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gruber, Sophia, Löf, Achim, Hausch, Adina, Kutzki, Fabian, Jöhr, Res, Obser, Tobias, König, Gesa, Schneppenheim, Reinhard, Aponte-Santamaría, Camilo, Gräter, Frauke, Brehm, Maria A., Benoit, Martin, Lipfert, Jan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Hematology 2022
Materias:	Thrombosis and Hemostasis
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631632/ https://www.ncbi.nlm.nih.gov/pubmed/36069828 http://dx.doi.org/10.1182/bloodadvances.2022006978

Ejemplares similares

Mechano-covalent protection of coagulation factor VIII by von Willebrand factor
por: Butera, Diego, et al.
Publicado: (2022)

Phenotypic and genetic characterizations of the Milan cohort of von Willebrand disease type 2
por: Seidizadeh, Omid, et al.
Publicado: (2022)

von Willebrand factor antigen levels are associated with burden of rare nonsynonymous variants in the VWF gene
por: Sadler, Brooke, et al.
Publicado: (2021)

Small interfering RNA–mediated allele-selective silencing of von Willebrand factor in vitro and in vivo
por: Jongejan, Yvonne K., et al.
Publicado: (2023)

Assembly of von Willebrand factor tubules with in vivo helical parameters requires A1 domain insertion
por: Javitt, Gabriel, et al.
Publicado: (2022)

A novel von Willebrand factor multimer ratio as marker of disease activity in thrombotic thrombocytopenic purpura
por: Falter, Tanja, et al.
Publicado: (2023)

Proximity proteomics identifies septins and PAK2 as decisive regulators of actomyosin-mediated expulsion of von Willebrand factor
por: El-Mansi, Sammy, et al.
Publicado: (2023)

Desmopressin response depends on the presence and type of genetic variants in patients with type 1 and type 2 von Willebrand disease
por: Atiq, Ferdows, et al.
Publicado: (2022)

von Willebrand factor modulates immune complexes and the recall response against factor VIII in a murine hemophilia A model
por: Oleshko, Olga, et al.
Publicado: (2023)

Single molecule force spectroscopy data and BD- and MD simulations on the blood protein von Willebrand factor
por: Posch, Sandra, et al.
Publicado: (2016)

Gain-of-Function Variant p.Pro2555Arg of von Willebrand Factor Increases Aggregate Size through Altering Stem Dynamics
por: Huck, Volker, et al.
Publicado: (2020)

VWF–ADAMTS13 axis dysfunction in children with sickle cell disease treated with hydroxycarbamide vs blood transfusion
por: Fogarty, Helen, et al.
Publicado: (2023)

Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition
por: Yu, Jia, et al.
Publicado: (2020)

Impaired factor V–related anticoagulant mechanisms and deep vein thrombosis associated with A2086D and W1920R mutations
por: Shimonishi, Naruto, et al.
Publicado: (2023)

A novel mouse whole blood thrombin generation assay sensitive to FXI- and FIX-mediated amplification of coagulation
por: Wan, Jun, et al.
Publicado: (2022)

Laminin G1 residues of protein S mediate its TFPI cofactor function and are competitively regulated by C4BP
por: Teraz-Orosz, Adrienn, et al.
Publicado: (2022)

Factor XII plays a pathogenic role in organ failure and death in baboons challenged with Staphylococcus aureus
por: Silasi, Robert, et al.
Publicado: (2021)

Multiplexed protein force spectroscopy reveals equilibrium protein folding dynamics and the low-force response of von Willebrand factor
por: Löf, Achim, et al.
Publicado: (2019)

Advancing multimer analysis of von Willebrand factor by single-molecule AFM imaging
por: Löf, Achim, et al.
Publicado: (2019)

The interplay between tissue plasminogen activator domains and fibrin structures in the regulation of fibrinolysis: kinetic and microscopic studies
por: Longstaff, Colin, et al.
Publicado: (2011)

Activated protein C cofactor function of protein S: a critical role for Asp95 in the EGF1-like domain
por: Andersson, Helena M., et al.
Publicado: (2010)

Harmful or Physiologic: Diagnosing Fibrinolysis Shutdown in a Trauma Cohort With Rotational Thromboelastometry
por: Gomez-Builes, J. Carolina, et al.
Publicado: (2018)

Platelets inhibit apoptotic lung epithelial cell death and protect mice against infection-induced lung injury
por: Bain, William, et al.
Publicado: (2019)

Targeting complement activation in COVID-19
por: Kulkarni, Hrishikesh S., et al.
Publicado: (2020)

COVID-19 and coagulation: bleeding and thrombotic manifestations of SARS-CoV-2 infection
por: Al-Samkari, Hanny, et al.
Publicado: (2020)

COVID-19 coagulopathy, thrombosis, and bleeding
por: Chan, Noel C., et al.
Publicado: (2020)

Frequency of venous thromboembolism in 6513 patients with COVID-19: a retrospective study
por: Hill, Jason B., et al.
Publicado: (2020)

A toolkit for the collection of thrombosis-related data elements in COVID-19 clinical studies
por: Siegal, Deborah M., et al.
Publicado: (2020)

Incidence of symptomatic, image-confirmed venous thromboembolism following hospitalization for COVID-19 with 90-day follow-up
por: Salisbury, Richard, et al.
Publicado: (2020)

Postdischarge thromboembolic outcomes and mortality of hospitalized patients with COVID-19: the CORE-19 registry
por: Giannis, Dimitrios, et al.
Publicado: (2021)

A factor VIIIa–mimetic bispecific antibody, Mim8, ameliorates bleeding upon severe vascular challenge in hemophilia A mice
por: Østergaard, Henrik, et al.
Publicado: (2021)

COVID-19 and VITT: same or different?
por: Arepally, Gowthami M.
Publicado: (2021)

An alternate covalent form of platelet αIIbβ3 integrin that resides in focal adhesions and has altered function
por: Pijning, Aster E., et al.
Publicado: (2021)

Novel mechanism regulating tissue factor activity
por: Nieuwland, Rienk
Publicado: (2021)

The incidence of cancer-associated thrombosis is increasing over time
por: Mahajan, Anjlee, et al.
Publicado: (2022)

The binding of autotaxin to integrins mediates hyperhomocysteinemia-potentiated platelet activation and thrombosis in mice and humans
por: Han, Lulu, et al.
Publicado: (2021)

Role of ribosomal RNA released from red cells in blood coagulation in zebrafish and humans
por: Alharbi, Abdulmajeed, et al.
Publicado: (2021)

Polyphosphate expression by cancer cell extracellular vesicles mediates binding of factor XII and contact activation
por: Shim, Young Jun, et al.
Publicado: (2021)

Most anti-PF4 antibodies in vaccine-induced immune thrombotic thrombocytopenia are transient
por: Schönborn, Linda, et al.
Publicado: (2022)

PKM2 promotes neutrophil activation and cerebral thromboinflammation: therapeutic implications for ischemic stroke
por: Dhanesha, Nirav, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_222gd9ejdl5254nbnqjdq9jb3q