Efflux capacity and aldehyde dehydrogenase both contribute to CD8(+) T-cell resistance to posttransplant cyclophosphamide

Mechanisms of T-cell survival after cytotoxic chemotherapy, including posttransplantation cyclophosphamide (PTCy), are not well understood. Here, we explored the impact of PTCy on human CD8(+) T-cell survival and reconstitution, including what cellular pathways drive PTCy resistance. In major histoc...

Descripción completa

Detalles Bibliográficos
Autores principales: Patterson, Michael T., Nunes, Natalia S., Wachsmuth, Lucas P., Panjabi, Amrit, Fletcher, Rochelle E., Khan, Shanzay M., Dimitrova, Dimana, Kanakry, Jennifer A., Luznik, Leo, Kanakry, Christopher G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2022
Materias:
Transplantation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631635/
https://www.ncbi.nlm.nih.gov/pubmed/35819449
http://dx.doi.org/10.1182/bloodadvances.2022006961

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631635/
https://www.ncbi.nlm.nih.gov/pubmed/35819449
http://dx.doi.org/10.1182/bloodadvances.2022006961

Ejemplares similares