Cargando…
Noncanonical Sonic Hedgehog signaling amplifies platelet reactivity and thrombogenicity
Sonic Hedgehog (Shh) is a morphogen in vertebrate embryos that is also associated with organ homeostasis in adults. We report here that human platelets, though enucleate, synthesize Shh from preexisting mRNAs upon agonist stimulation, and mobilize it for surface expression and release on extracellul...
| Autores principales: | , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society of Hematology
2022
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631642/ https://www.ncbi.nlm.nih.gov/pubmed/35704688 http://dx.doi.org/10.1182/bloodadvances.2021006560 |