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Noncanonical Sonic Hedgehog signaling amplifies platelet reactivity and thrombogenicity

Sonic Hedgehog (Shh) is a morphogen in vertebrate embryos that is also associated with organ homeostasis in adults. We report here that human platelets, though enucleate, synthesize Shh from preexisting mRNAs upon agonist stimulation, and mobilize it for surface expression and release on extracellul...

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Detalles Bibliográficos
Autores principales:	Tiwari, Arundhati, Gautam, Deepa, Kulkarni, Paresh P., Ekhlak, Mohammad, Sonkar, Vijay K., Agrawal, Vikas, Dash, Debabrata
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Hematology 2022
Materias:	Thrombosis and Hemostasis
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631642/ https://www.ncbi.nlm.nih.gov/pubmed/35704688 http://dx.doi.org/10.1182/bloodadvances.2021006560

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