In vivo genome-wide CRISPR screening in murine acute myeloid leukemia uncovers microenvironmental dependencies

Genome-wide CRISPR screens have been extremely useful in identifying therapeutic targets in diverse cancers by defining genes that are essential for malignant growth. However, most CRISPR screens were performed in vitro and thus cannot identify genes that are essential for interactions with the micr...

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Detalles Bibliográficos
Autores principales: Mercier, Francois E., Shi, Jiantao, Sykes, David B., Oki, Toshihiko, Jankovic, Maja, Man, Cheuk Him, Kfoury, Youmna S., Miller, Elizabeth, He, Shutao, Zhu, Alexander, Vasic, Radovan, Doench, John, Orthwein, Alexandre, Michor, Franziska, Scadden, David T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2022
Materias:
Myeloid Neoplasia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631646/
https://www.ncbi.nlm.nih.gov/pubmed/35793392
http://dx.doi.org/10.1182/bloodadvances.2022007250

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631646/
https://www.ncbi.nlm.nih.gov/pubmed/35793392
http://dx.doi.org/10.1182/bloodadvances.2022007250

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