HMGA2 expression defines a subset of human AML with immature transcriptional signature and vulnerability to G2/M inhibition

High-mobility group AT-hook 2 (HMGA2) is a nonhistone chromatin-binding protein that is normally expressed in stem cells of various tissues and aberrantly detected in several tumor types. We recently observed that one-fourth of human acute myeloid leukemia (AML) specimens express HMGA2, which associ...

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Detalles Bibliográficos
Autores principales: Moison, Céline, Spinella, Jean-François, Chagraoui, Jalila, Lavallée, Vincent-Philippe, Lehnertz, Bernhard, Thiollier, Clarisse, Boivin, Isabel, Mayotte, Nadine, MacRae, Tara, Marinier, Anne, Hébert, Josée, Sauvageau, Guy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2022
Materias:
Myeloid Neoplasia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631656/
https://www.ncbi.nlm.nih.gov/pubmed/35797243
http://dx.doi.org/10.1182/bloodadvances.2021005828

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631656/
https://www.ncbi.nlm.nih.gov/pubmed/35797243
http://dx.doi.org/10.1182/bloodadvances.2021005828

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