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Closed-loop control of continuous piperacillin delivery: An in silico study
Background and objective: Sub-therapeutic dosing of piperacillin-tazobactam in critically-ill patients is associated with poor clinical outcomes and may promote the emergence of drug-resistant infections. In this paper, an in silico investigation of whether closed-loop control can improve pharmacoki...
Autores principales: | Herrero, Pau, Wilson, Richard C., Armiger, Ryan, Roberts, Jason A., Holmes, Alison, Georgiou, Pantelis, Rawson, Timothy M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631830/ https://www.ncbi.nlm.nih.gov/pubmed/36338121 http://dx.doi.org/10.3389/fbioe.2022.1015389 |
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