Synthesis and Antitumor Activities of Novel Mitochondria-Targeted Dihydroartemisinin Ether Derivatives

[Image: see text] Ten novel mitochondria-targeted dihydroartemisinin ether derivatives were designed, synthesized, and evaluated for antitumor activity against five cancer cell lines in vitro. Profoundly, compound D8-T (IC(50) = 56.9 nM) showed the most potent antiproliferative activity against the...

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Detalles Bibliográficos
Autores principales: Xu, Cangcang, Xiao, Linfan, Lin, Peiyu, Yang, Xiyue, Zou, Xin, Mu, Lingli, Yang, Xiaoping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631890/
https://www.ncbi.nlm.nih.gov/pubmed/36340114
http://dx.doi.org/10.1021/acsomega.2c04562

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631890/
https://www.ncbi.nlm.nih.gov/pubmed/36340114
http://dx.doi.org/10.1021/acsomega.2c04562

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