Bromodomain Interactions with Acetylated Histone 4 Peptides in the BRD4 Tandem Domain: Effects on Domain Dynamics and Internal Flexibility

[Image: see text] The bromodomain and extra-terminal (BET) protein BRD4 regulates gene expression via recruitment of transcriptional regulatory complexes to acetylated chromatin. Like other BET proteins, BRD4 contains two bromodomains, BD1 and BD2, that can interact cooperatively with target protein...

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Detalles Bibliográficos
Autores principales: Wernersson, Sven, Bobby, Romel, Flavell, Liz, Milbradt, Alexander G., Holdgate, Geoffrey A., Embrey, Kevin J., Akke, Mikael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631989/
https://www.ncbi.nlm.nih.gov/pubmed/36215732
http://dx.doi.org/10.1021/acs.biochem.2c00226

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631989/
https://www.ncbi.nlm.nih.gov/pubmed/36215732
http://dx.doi.org/10.1021/acs.biochem.2c00226

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