Cargando…

Bromodomain Interactions with Acetylated Histone 4 Peptides in the BRD4 Tandem Domain: Effects on Domain Dynamics and Internal Flexibility

[Image: see text] The bromodomain and extra-terminal (BET) protein BRD4 regulates gene expression via recruitment of transcriptional regulatory complexes to acetylated chromatin. Like other BET proteins, BRD4 contains two bromodomains, BD1 and BD2, that can interact cooperatively with target protein...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wernersson, Sven, Bobby, Romel, Flavell, Liz, Milbradt, Alexander G., Holdgate, Geoffrey A., Embrey, Kevin J., Akke, Mikael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631989/ https://www.ncbi.nlm.nih.gov/pubmed/36215732 http://dx.doi.org/10.1021/acs.biochem.2c00226

Ejemplares similares

Segmental Isotope Labelling of an Individual Bromodomain of a Tandem Domain BRD4 Using Sortase A
por: Williams, Felix P., et al.
Publicado: (2016)

NMR Molecular Replacement Provides New Insights into Binding Modes to Bromodomains of BRD4 and TRIM24
por: Torres, Felix, et al.
Publicado: (2022)

Solution structure of the second bromodomain of Brd2 and its specific interaction with acetylated histone tails
por: Huang, Hongda, et al.
Publicado: (2007)

Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors
por: Ember, Stuart W. J., et al.
Publicado: (2014)

Interrogating Histone Acetylation and BRD4 as Mitotic Bookmarks of Transcription
por: Behera, Vivek, et al.
Publicado: (2019)

Bromodomain-Containing Protein BRD4 Is Hyperphosphorylated in Mitosis
por: Wang, Ranran, et al.
Publicado: (2020)

BRD3 and BRD4 BET Bromodomain Proteins Differentially Regulate Skeletal Myogenesis
por: Roberts, Thomas C., et al.
Publicado: (2017)

Biophysical methods in early drug discovery
por: Holdgate, Geoffrey, et al.
Publicado: (2019)

Regulation of Carbohydrate-Responsive Metabolic Genes by Histone Acetylation and the Acetylated Histone Reader BRD4 in the Gene Body Region
por: Mochizuki, Kazuki, et al.
Publicado: (2021)

Affinity Map of Bromodomain Protein 4 (BRD4) Interactions with the Histone H4 Tail and the Small Molecule Inhibitor JQ1
por: Jung, Marie, et al.
Publicado: (2014)

Preparation data of the bromodomains BRD3(1), BRD3(2), BRD4(1), and BRPF1B and crystallization of BRD4(1)-inhibitor complexes
por: Hügle, Martin, et al.
Publicado: (2016)

Dissecting the Role of BET Bromodomain Proteins BRD2 and BRD4 in Human NK Cell Function
por: Cribbs, Adam P., et al.
Publicado: (2021)

BET Bromodomain Proteins Brd2, Brd3 and Brd4 Selectively Regulate Metabolic Pathways in the Pancreatic β-Cell
por: Deeney, Jude T., et al.
Publicado: (2016)

The bromodomain protein BRD4 regulates splicing during heat shock
por: Hussong, Michelle, et al.
Publicado: (2017)

Transcriptional regulation of autophagy and lysosomal function by bromodomain protein BRD4
por: Sakamaki, Jun-Ichi, et al.
Publicado: (2017)

Bromodomain Protein BRD4 Is Essential for Hair Cell Function and Survival
por: Kannan-Sundhari, Abhiraami, et al.
Publicado: (2020)

The Bromodomain Protein Brd4 Insulates Chromatin from DNA Damage Signaling
por: Floyd, Scott R., et al.
Publicado: (2013)

Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4
por: Zengerle, Michael, et al.
Publicado: (2015)

Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function
por: Sakamaki, Jun-ichi, et al.
Publicado: (2017)

Alchemical Free Energy Methods Applied to Complexes of the First Bromodomain of BRD4
por: Guest, Ellen E., et al.
Publicado: (2022)

Coordination of Di-Acetylated Histone Ligands by the ATAD2 Bromodomain
por: Evans, Chiara M., et al.
Publicado: (2021)

Histone H4 acetylation and the epigenetic reader Brd4 are critical regulators of pluripotency in embryonic stem cells
por: Gonzales-Cope, Michelle, et al.
Publicado: (2016)

Epigenetic targeting of bromodomain protein BRD4 counteracts cancer cachexia and prolongs survival
por: Segatto, Marco, et al.
Publicado: (2017)

Dicer promotes genome stability via the bromodomain transcriptional co-activator BRD4
por: Gutbrod, M. J., et al.
Publicado: (2022)

Native Mass Spectrometry of BRD4 Bromodomains Linked to a Long Disordered Region
por: Azegami, Nanako, et al.
Publicado: (2022)

Targeting bromodomain-containing protein 4 (BRD4) inhibits MYC expression in colorectal cancer cells
por: Otto, C., et al.
Publicado: (2019)

Bromodomain-containing protein 4 (BRD4) as an epigenetic regulator of fatty acid metabolism genes and ferroptosis
por: Yang, Minghua, et al.
Publicado: (2022)

The KAT5-Acetyl-Histone4-Brd4 axis silences HIV-1 transcription and promotes viral latency
por: Li, Zichong, et al.
Publicado: (2018)

Evolutionary conserved NSL complex/BRD4 axis controls transcription activation via histone acetylation
por: Gaub, Aline, et al.
Publicado: (2020)

Isoxazole‐Derived Amino Acids are Bromodomain‐Binding Acetyl‐Lysine Mimics: Incorporation into Histone H4 Peptides and Histone H3
por: Sekirnik (née Measures), Angelina R., et al.
Publicado: (2016)

Designing Dual Inhibitors of Anaplastic Lymphoma Kinase (ALK) and Bromodomain-4 (BRD4) by Tuning Kinase Selectivity
por: Watts, Ellen, et al.
Publicado: (2019)

A Bromodomain-Containing Protein 4 (BRD4) Inhibitor Suppresses Angiogenesis by Regulating AP-1 Expression
por: Zhou, Zijun, et al.
Publicado: (2020)

Bromodomain Protein BRD4 Is Required for Estrogen Receptor-Dependent Enhancer Activation and Gene Transcription
por: Nagarajan, Sankari, et al.
Publicado: (2014)

Attach-Pull-Release Calculations of Ligand Binding and Conformational Changes on the First BRD4 Bromodomain
por: Heinzelmann, Germano, et al.
Publicado: (2017)

Bromodomain protein BRD4 directs and sustains CD8 T cell differentiation during infection
por: Milner, J. Justin, et al.
Publicado: (2021)

Bromodomain Protein BRD4-Mediated Mutant p53 Transcription Promotes TNBC Progression
por: Zhou, Julie Xia, et al.
Publicado: (2022)

Brd4 engagement from chromatin targeting to transcriptional regulation: selective contact with acetylated histone H3 and H4
por: Chiang, Cheng-Ming
Publicado: (2009)

Spatially restricted loading of BRD2 at DNA double-strand breaks protects H4 acetylation domains and promotes DNA repair
por: Gursoy-Yuzugullu, Ozge, et al.
Publicado: (2017)

Monitoring Ras Interactions with the Nucleotide Exchange Factor Son of Sevenless (Sos) Using Site-specific NMR Reporter Signals and Intrinsic Fluorescence
por: Vo, Uybach, et al.
Publicado: (2016)

Identification of bromodomain-containing protein 4 (BRD4) as a novel marker and epigenetic target in mast cell leukemia
por: Wedeh, Ghaith, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_qq48kkkqd6d9j977qfns29gvfu