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Profile and Predictors of Blood Tumor Mutational Burden in Advanced Hepatocellular Carcinoma
Advanced hepatocellular carcinoma (HCC) is responsive to immune checkpoint inhibitors, but there are currently no known biomarkers to predict treatment benefit. Blood TMB (bTMB) estimation via circulating tumor DNA (ctDNA) profiling can provide a convenient means to estimate HCC TMB. Here we provide...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9632309/ https://www.ncbi.nlm.nih.gov/pubmed/36103364 http://dx.doi.org/10.1093/oncolo/oyac189 |
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author | Franses, Joseph W Lim, Mir Burgoyne, Adam M Mody, Kabir Lennerz, Jochen Chang, Jeremy Imperial, Robin Dybel, Stacey N Dinh, Thi M Masannat, Jude Weipert, Caroline M Hsiehchen, David |
author_facet | Franses, Joseph W Lim, Mir Burgoyne, Adam M Mody, Kabir Lennerz, Jochen Chang, Jeremy Imperial, Robin Dybel, Stacey N Dinh, Thi M Masannat, Jude Weipert, Caroline M Hsiehchen, David |
author_sort | Franses, Joseph W |
collection | PubMed |
description | Advanced hepatocellular carcinoma (HCC) is responsive to immune checkpoint inhibitors, but there are currently no known biomarkers to predict treatment benefit. Blood TMB (bTMB) estimation via circulating tumor DNA (ctDNA) profiling can provide a convenient means to estimate HCC TMB. Here we provide the first landscape of bTMB in advanced HCC using a commercially available next-generation sequencing assay, show that it is approximately three times as high as matched tissue TMB, and show that bTMB correlates with NAFLD cirrhosis etiology and the presence of genomic alterations in HTERT and TP53. These results lay the foundation for subsequent studies evaluating bTMB as an immune therapy predictive biomarker in HCC. |
format | Online Article Text |
id | pubmed-9632309 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-96323092022-11-04 Profile and Predictors of Blood Tumor Mutational Burden in Advanced Hepatocellular Carcinoma Franses, Joseph W Lim, Mir Burgoyne, Adam M Mody, Kabir Lennerz, Jochen Chang, Jeremy Imperial, Robin Dybel, Stacey N Dinh, Thi M Masannat, Jude Weipert, Caroline M Hsiehchen, David Oncologist Brief Communication Advanced hepatocellular carcinoma (HCC) is responsive to immune checkpoint inhibitors, but there are currently no known biomarkers to predict treatment benefit. Blood TMB (bTMB) estimation via circulating tumor DNA (ctDNA) profiling can provide a convenient means to estimate HCC TMB. Here we provide the first landscape of bTMB in advanced HCC using a commercially available next-generation sequencing assay, show that it is approximately three times as high as matched tissue TMB, and show that bTMB correlates with NAFLD cirrhosis etiology and the presence of genomic alterations in HTERT and TP53. These results lay the foundation for subsequent studies evaluating bTMB as an immune therapy predictive biomarker in HCC. Oxford University Press 2022-09-14 /pmc/articles/PMC9632309/ /pubmed/36103364 http://dx.doi.org/10.1093/oncolo/oyac189 Text en © The Author(s) 2022. Published by Oxford University Press. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Brief Communication Franses, Joseph W Lim, Mir Burgoyne, Adam M Mody, Kabir Lennerz, Jochen Chang, Jeremy Imperial, Robin Dybel, Stacey N Dinh, Thi M Masannat, Jude Weipert, Caroline M Hsiehchen, David Profile and Predictors of Blood Tumor Mutational Burden in Advanced Hepatocellular Carcinoma |
title | Profile and Predictors of Blood Tumor Mutational Burden in Advanced Hepatocellular Carcinoma |
title_full | Profile and Predictors of Blood Tumor Mutational Burden in Advanced Hepatocellular Carcinoma |
title_fullStr | Profile and Predictors of Blood Tumor Mutational Burden in Advanced Hepatocellular Carcinoma |
title_full_unstemmed | Profile and Predictors of Blood Tumor Mutational Burden in Advanced Hepatocellular Carcinoma |
title_short | Profile and Predictors of Blood Tumor Mutational Burden in Advanced Hepatocellular Carcinoma |
title_sort | profile and predictors of blood tumor mutational burden in advanced hepatocellular carcinoma |
topic | Brief Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9632309/ https://www.ncbi.nlm.nih.gov/pubmed/36103364 http://dx.doi.org/10.1093/oncolo/oyac189 |
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