Gain-of-function of TRPM4 predisposes mice to psoriasiform dermatitis

Transient receptor potential melastatin 4 (TRPM4) is a Ca(2+)-activated, monovalent cation channel that is expressed in a wide range of cells. We previously reported two gain-of-function (GoF) mutations of TRPM4 as the cause of progressive symmetric erythrokeratodermia (PSEK), which shares similar c...

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Detalles Bibliográficos
Autores principales: Yamada, Daisuke, Vu, Simon, Wu, Xuesong, Shi, Zhenrui, Morris, Desiree, Bloomstein, Joshua D., Huynh, Mindy, Zheng, Jie, Hwang, Samuel T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9632438/
https://www.ncbi.nlm.nih.gov/pubmed/36341417
http://dx.doi.org/10.3389/fimmu.2022.1025499

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9632438/
https://www.ncbi.nlm.nih.gov/pubmed/36341417
http://dx.doi.org/10.3389/fimmu.2022.1025499

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