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Phosphoinositide species and filamentous actin formation mediate engulfment by senescent tumor cells

Cancer cells survive chemotherapy and cause lethal relapse by entering a senescent state that facilitates expression of many phagocytosis/macrophage-related genes that engender a novel cannibalism phenotype. We used biosensors and live-cell imaging to reveal the basic steps and mechanisms of engulfm...

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Detalles Bibliográficos
Autores principales: Frey, Wesley D., Anderson, Ashlyn Y., Lee, Hyemin, Nguyen, Julie B., Cowles, Emma L., Lu, Hua, Jackson, James G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9632905/
https://www.ncbi.nlm.nih.gov/pubmed/36279312
http://dx.doi.org/10.1371/journal.pbio.3001858