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Phosphoinositide species and filamentous actin formation mediate engulfment by senescent tumor cells
Cancer cells survive chemotherapy and cause lethal relapse by entering a senescent state that facilitates expression of many phagocytosis/macrophage-related genes that engender a novel cannibalism phenotype. We used biosensors and live-cell imaging to reveal the basic steps and mechanisms of engulfm...
Autores principales: | Frey, Wesley D., Anderson, Ashlyn Y., Lee, Hyemin, Nguyen, Julie B., Cowles, Emma L., Lu, Hua, Jackson, James G. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9632905/ https://www.ncbi.nlm.nih.gov/pubmed/36279312 http://dx.doi.org/10.1371/journal.pbio.3001858 |
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