Desmin intermediate filaments and tubulin detyrosination stabilize growing microtubules in the cardiomyocyte

In heart failure, an increased abundance of post-translationally detyrosinated microtubules stiffens the cardiomyocyte and impedes its contractile function. Detyrosination promotes interactions between microtubules, desmin intermediate filaments, and the sarcomere to increase cytoskeletal stiffness,...

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Detalles Bibliográficos
Autores principales: Salomon, Alexander K., Phyo, Sai Aung, Okami, Naima, Heffler, Julie, Robison, Patrick, Bogush, Alexey I., Prosser, Benjamin L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Original Contribution
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9633452/
https://www.ncbi.nlm.nih.gov/pubmed/36326891
http://dx.doi.org/10.1007/s00395-022-00962-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9633452/
https://www.ncbi.nlm.nih.gov/pubmed/36326891
http://dx.doi.org/10.1007/s00395-022-00962-3

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