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Desmin intermediate filaments and tubulin detyrosination stabilize growing microtubules in the cardiomyocyte
In heart failure, an increased abundance of post-translationally detyrosinated microtubules stiffens the cardiomyocyte and impedes its contractile function. Detyrosination promotes interactions between microtubules, desmin intermediate filaments, and the sarcomere to increase cytoskeletal stiffness,...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Berlin Heidelberg
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9633452/ https://www.ncbi.nlm.nih.gov/pubmed/36326891 http://dx.doi.org/10.1007/s00395-022-00962-3 |