Cargando…

PIK3CA-mutations in breast cancer

PURPOSE: Phosphatidylinositide-3-kinase (PI3K) regulates proliferation and apoptosis; somatic PIK3CA-mutations may activate these processes. Aim of this study was to determine the prevalence of PIK3CA-mutations in a cohort of early stage breast cancer patients and the association to the course of di...

Descripción completa

Detalles Bibliográficos
Autores principales:	Reinhardt, Kristin, Stückrath, Kathrin, Hartung, Carolin, Kaufhold, Sandy, Uleer, Christoph, Hanf, Volker, Lantzsch, Tillmann, Peschel, Susanne, John, Jutta, Pöhler, Marleen, Bauer, Marcus, Bürrig, Friedrich Karl, Weigert, Edith, Buchmann, Jörg, Kantelhardt, Eva Johanna, Thomssen, Christoph, Vetter, Martina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2022
Materias:	Preclinical Study
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9633529/ https://www.ncbi.nlm.nih.gov/pubmed/36279023 http://dx.doi.org/10.1007/s10549-022-06637-w

Ejemplares similares

Prognostic Value of Tumour-Infiltrating Lymphocytes in an Unselected Cohort of Breast Cancer Patients
por: Schüler, Kathleen, et al.
Publicado: (2022)

Proteomic profiling of breast cancer metabolism identifies SHMT2 and ASCT2 as prognostic factors
por: Bernhardt, Stephan, et al.
Publicado: (2017)

Specific allelic variants of SNPs in the MDM2 and MDMX genes are associated with earlier tumor onset and progression in Caucasian breast cancer patients
por: Bauer, Marcus, et al.
Publicado: (2019)

Intrinsic subtypes in Ethiopian breast cancer patient
por: Desalegn, Zelalem, et al.
Publicado: (2022)

Mutations in PIK3CA sensitize breast cancer cells to physiologic levels of aspirin
por: Turturro, Sanja B., et al.
Publicado: (2016)

Antitumor activity of the PI3K δ-sparing inhibitor MEN1611 in PIK3CA mutated, trastuzumab-resistant HER2 + breast cancer
por: Fiascarelli, Alessio, et al.
Publicado: (2023)

Prospective evaluation of prognostic factors uPA/PAI-1 in node-negative breast cancer: Phase III NNBC3-Europe trial (AGO, GBG, EORTC-PBG) comparing 6 × FEC versus 3 × FEC/3 × Docetaxel
por: Kantelhardt, Eva J, et al.
Publicado: (2011)

Profiling metabolic changes in breast cancer with targeted proteomics
por: Bernhardt, Stephan, et al.
Publicado: (2014)

FNTB Promoter Polymorphisms Are Independent Predictors of Survival in Patients with Triple Negative Breast Cancer
por: Bachmann, Hagen Sjard, et al.
Publicado: (2022)

Synergistic cytotoxicity of the CDK4 inhibitor Fascaplysin in combination with EGFR inhibitor Afatinib against Non-small Cell Lung Cancer
por: Plangger, Adelina, et al.
Publicado: (2021)

Associations of Interleukin-5 With Plaque Development and Cardiovascular Events
por: Knutsson, Anki, et al.
Publicado: (2019)

Effects of salinomycin and niclosamide on small cell lung cancer and small cell lung cancer circulating tumor cell lines
por: Hochmair, Maximilian, et al.
Publicado: (2019)

Association of caspase 8 polymorphisms -652 6N InsDel and Asp302His with progression-free survival and tumor infiltrating lymphocytes in early breast cancer
por: Kuhlmann, Jan Dominik, et al.
Publicado: (2019)

DC-SCRIPT is a novel regulator of the tumor suppressor gene CDKN2B and induces cell cycle arrest in ERα-positive breast cancer cells
por: Ansems, Marleen, et al.
Publicado: (2015)

Adjuvant Docetaxel in Node-Negative Breast Cancer Patients: A Randomized Trial of AGO-Breast Study Group, German Breast Group, and EORTC-Pathobiology Group
por: Thomssen, Christoph, et al.
Publicado: (2023)

RC0639: phase II study of paclitaxel, trastuzumab, and lapatinib as adjuvant therapy for early stage HER2-positive breast cancer
por: Moreno-Aspitia, Alvaro, et al.
Publicado: (2013)

Western Diet-Fed, Aortic-Banded Ossabaw Swine: A Preclinical Model of Cardio-Metabolic Heart Failure
por: Olver, T. Dylan, et al.
Publicado: (2019)

Immunohistochemistry and fluorescence in situ hybridization assessment of HER2 in clinical trials of adjuvant therapy for breast cancer (NCCTG N9831, BCIRG 006, and BCIRG 005)
por: Perez, Edith A., et al.
Publicado: (2013)

Comparison of Receptor-Defined Breast Cancer Subtypes Between German and Sudanese Women: A Facility-Based Cohort Study
por: Sengal, Asmerom Tesfamariam, et al.
Publicado: (2017)

Multifocal invasive ductal breast cancer with osteoclast-like giant cells: a case report
por: Richter, Georg, et al.
Publicado: (2011)

The prevalence of estrogen receptor-negative breast cancer in Ethiopia
por: Kantelhardt, Eva Johanna, et al.
Publicado: (2014)

Nebenwirkungsmanagement immunonkologischer Therapien – was gibt es zu beachten?
por: Thomssen, Christoph
Publicado: (2022)

Central carbon metabolism in the progression of mammary carcinoma
por: Richardson, Adam D., et al.
Publicado: (2007)

The spectrum of ATM missense variants and their contribution to contralateral breast cancer
por: Broeks, Annegien, et al.
Publicado: (2007)

Stromal mast cells in invasive breast cancer are a marker of favourable prognosis: a study of 4,444 cases
por: Rajput, Ashish B., et al.
Publicado: (2007)

Loss of expression of FANCD2 protein in sporadic and hereditary breast cancer
por: van der Groep, Petra, et al.
Publicado: (2007)

Preclinical activity of gefitinib in non-keratinizing nasopharyngeal carcinoma cell lines and biomarkers of response
por: Ma, Brigette B.Y., et al.
Publicado: (2009)

Paclitaxel in self-micro emulsifying formulations: oral bioavailability study in mice
por: Oostendorp, Roos L., et al.
Publicado: (2010)

Pankiller effect of prolonged exposure to menadione on glioma cells: potentiation by vitamin C
por: Vita, Marina F., et al.
Publicado: (2010)

Long-term blinded placebo-controlled study of SNT-MC17/idebenone in the dystrophin deficient mdx mouse: cardiac protection and improved exercise performance
por: Buyse, Gunnar M., et al.
Publicado: (2009)

Development and characterization of CD22-targeted pegylated-liposomal doxorubicin (IL-PLD)
por: O’Donnell, Robert T., et al.
Publicado: (2009)

Acute atrial tachyarrhythmia induces angiotensin II type 1 receptor-mediated oxidative stress and microvascular flow abnormalities in the ventricles
por: Goette, Andreas, et al.
Publicado: (2009)

CD36-mediated activation of endothelial cell apoptosis by an N-terminal recombinant fragment of thrombospondin-2 inhibits breast cancer growth and metastasis in vivo
por: Koch, Manuel, et al.
Publicado: (2010)

Genomic analysis identifies unique signatures predictive of brain, lung, and liver relapse
por: Harrell, J. Chuck, et al.
Publicado: (2011)

Role of ghrelin in food reward: impact of ghrelin on sucrose self-administration and mesolimbic dopamine and acetylcholine receptor gene expression
por: Skibicka, Karolina P, et al.
Publicado: (2012)

Growth inhibition induced by antiprogestins RU-38486, ORG-31710, and CDB-2914 in ovarian cancer cells involves inhibition of cyclin dependent kinase 2
por: Goyeneche, Alicia A., et al.
Publicado: (2011)

Glutamatergic regulation of ghrelin-induced activation of the mesolimbic dopamine system
por: Jerlhag, Elisabet, et al.
Publicado: (2011)

Antiproliferative activity, mechanism of action and oral antitumor activity of CP-4126, a fatty acid derivative of gemcitabine, in in vitro and in vivo tumor models
por: Bergman, Andries M., et al.
Publicado: (2010)

Genome-Wide Association Studies (GWAS) breast cancer susceptibility loci in Arabs: susceptibility and prognostic implications in Tunisians
por: Shan, Jingxuan, et al.
Publicado: (2012)

Expression of the BRCA1 complex member BRE predicts disease free survival in breast cancer
por: Noordermeer, Sylvie M., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_gursldrciaucn4hs4mg7gubtdt