Glycosylated clusterin species facilitate Aβ toxicity in human neurons

Clusterin (CLU) is one of the most significant genetic risk factors for late onset Alzheimer’s disease (AD). However, the mechanisms by which CLU contributes to AD development and pathogenesis remain unclear. Studies have demonstrated that the trafficking and localisation of glycosylated CLU protein...

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Detalles Bibliográficos
Autores principales: Foster, Evangeline M., Fernandes, Marco, Dangla-Valls, Adria, Hublitz, Philip, Pangalos, Menelaos, Lovestone, Simon, Ribe, Elena M., Buckley, Noel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9633591/
https://www.ncbi.nlm.nih.gov/pubmed/36329114
http://dx.doi.org/10.1038/s41598-022-23167-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9633591/
https://www.ncbi.nlm.nih.gov/pubmed/36329114
http://dx.doi.org/10.1038/s41598-022-23167-z

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