The methyltransferase domain of DNMT1 is an essential domain in acute myeloid leukemia independent of DNMT3A mutation

Aberrant DNA methylation patterns are a prominent feature of cancer. Methylation of DNA is mediated by the DNA methyltransferase (DNMT) protein family, which regulates de novo (DNMT3A and DNMT3B) and maintenance (DNMT1) methylation. Mutations in DNMT3A are observed in approximately 22% of acute myel...

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Detalles Bibliográficos
Autores principales: Bhogal, Balpreet, Weir, Barbara A., Crescenzo, Ramona, Marien, Ann, Kwon, Min Chul, Philippar, Ulrike, Cowley, Glenn S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9633652/
https://www.ncbi.nlm.nih.gov/pubmed/36329185
http://dx.doi.org/10.1038/s42003-022-04139-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9633652/
https://www.ncbi.nlm.nih.gov/pubmed/36329185
http://dx.doi.org/10.1038/s42003-022-04139-5

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