Cargando…

S-Equol enhances osteoblastic bone formation and prevents bone loss through OPG/RANKL via the PI3K/Akt pathway in streptozotocin-induced diabetic rats

BACKGROUND: This study aimed to explore whether S-Equol delays diabetes-induced osteoporosis and the molecular mechanisms underlying its therapeutic effects. MATERIALS AND METHODS: Thirty-five male Sprague–Dawley rats were randomized into five groups. The diabetic osteoporosis (DOP) group and three...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Zhe, Xu, Jing, Li, Shuo, Cui, Hanqiang, Zhang, Guiming, Ni, Xiangmin, Wang, Jian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Nutrition
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9633996/ https://www.ncbi.nlm.nih.gov/pubmed/36337646 http://dx.doi.org/10.3389/fnut.2022.986192

Ejemplares similares

Gadus morhua Eggs Sialoglycoprotein Prevent Estrogen Deficiency-Induced High Bone Turnover by Controlling OPG/RANKL/TRAF6 Pathway and Serum Metabolism
por: Zhao, Meihui, et al.
Publicado: (2022)

Biology of the RANKL–RANK–OPG System in Immunity, Bone, and Beyond
por: Walsh, Matthew C., et al.
Publicado: (2014)

Serum RANKL, osteoprotegerin (OPG), and RANKL/OPG ratio in nephrotic children
por: Wasilewska, Anna, et al.
Publicado: (2010)

Propofol attenuates osteoclastogenesis by lowering RANKL/OPG ratio in mouse osteoblasts
por: Lee, Do-Won, et al.
Publicado: (2018)

Fuscoside Attenuates Bone Loss in Bone Defects by Regulating The Rankl/Nlrp3/Opg Pathway in Rats
por: Liu, Xiangwei, et al.
Publicado: (2021)

Soy Isoflavones and Bone Health: Focus on the RANKL/RANK/OPG Pathway
por: Hooshiar, Saeedeh Hosseini, et al.
Publicado: (2022)

Salidroside Improves Bone Histomorphology and Prevents Bone Loss in Ovariectomized Diabetic Rats by Upregulating the OPG/RANKL Ratio
por: Zheng, Hongxing, et al.
Publicado: (2018)

Association between low bone mass and the serum RANKL and OPG in patients with nephrolithiasis
por: Mansour, Asieh, et al.
Publicado: (2018)

RANKL-RANK signaling regulates osteoblast differentiation and bone formation
por: Cao, Xu
Publicado: (2018)

High-Dose Diosgenin Reduces Bone Loss in Ovariectomized Rats via Attenuation of the RANKL/OPG Ratio
por: Zhang, Zhiguo, et al.
Publicado: (2014)

Dysregulated B Cell Expression of RANKL and OPG Correlates with Loss of Bone Mineral Density in HIV Infection
por: Titanji, Kehmia, et al.
Publicado: (2014)

Effect of enhanced masticatory force on OPG, RANKL and MGF in alveolar bone of ovariectomized rats
por: Ma, Zongmin, et al.
Publicado: (2020)

RANKL/RANK/OPG Pathway: A Mechanism Involved in Exercise-Induced Bone Remodeling
por: Tobeiha, Mohammad, et al.
Publicado: (2020)

TRAP5b and RANKL/OPG Predict Bone Pathology in Patients with Gaucher Disease
por: Ivanova, Margarita, et al.
Publicado: (2021)

The RANK/RANKL/OPG system and tumor bone metastasis: Potential mechanisms and therapeutic strategies
por: Zhang, Yan, et al.
Publicado: (2022)

Vitamin D inhibits bone loss in mice with thyrotoxicosis by activating the OPG/RANKL and Wnt/β-catenin signaling pathways
por: Xu, Dan, et al.
Publicado: (2022)

Melatonin inhibits osteoclastogenesis via RANKL/OPG suppression mediated by Rev‐Erbα in osteoblasts
por: Tian, Yihao, et al.
Publicado: (2022)

The Role of Inflammatory Cytokines, the RANKL/OPG Axis, and the Immunoskeletal Interface in Physiological Bone Turnover and Osteoporosis
por: Weitzmann, M. Neale
Publicado: (2013)

RANK/RANKL/OPG Signaling Pathways in Necrotic Jaw Bone from Bisphosphonate-Treated Subjects
por: Nisio, C. Di, et al.
Publicado: (2015)

RANKL/RANK/OPG system beyond bone remodeling: involvement in breast cancer and clinical perspectives
por: Infante, Marco, et al.
Publicado: (2019)

Adiponectin regulates bone mass in AIS osteopenia via RANKL/OPG and IL6 pathway
por: Zhang, Hong-qi, et al.
Publicado: (2019)

Regulatory Effects and Interactions of the Wnt and OPG-RANKL-RANK Signaling at the Bone-Cartilage Interface in Osteoarthritis
por: Kovács, Béla, et al.
Publicado: (2019)

Bone Metabolism and RANKL/OPG Ratio in Rheumatoid Arthritis Women Treated with TNF-α Inhibitors
por: Jura-Półtorak, Agnieszka, et al.
Publicado: (2021)

Mechanism of genistein regulating the differentiation of vascular smooth muscle cells into osteoblasts via the OPG/RANKL pathway
por: Shen, Cheng, et al.
Publicado: (2017)

Probiotic Propionibacterium freudenreichii MJ2 Enhances Osteoblast Differentiation and Mineralization by Increasing the OPG/RANKL Ratio
por: Yeom, Jiah, et al.
Publicado: (2021)

Influence of Polymorphisms in the RANKL/RANK/OPG Signaling Pathway on Volumetric Bone Mineral Density and Bone Geometry at the Forearm in Men
por: Roshandel, Delnaz, et al.
Publicado: (2011)

Bone mineral density in egyptian children with juvenile idiopathic arthritis: possible correlation to serum RANKL / osteoprotegerin (OPG) ratio and OPG gene polymorphisms
por: Eid, Riham, et al.
Publicado: (2023)

RANK/RANKL/OPG system in the intervertebral disc
por: Takegami, Norihiko, et al.
Publicado: (2017)

Effect of sumac extract on serum oxidative status, RANKL/OPG system and alveolar bone loss in experimental periodontitis in rats
por: SAĞLAM, Mehmet, et al.
Publicado: (2015)

Therapeutic effect of Shinkiwhan, herbal medicine, regulates OPG/RANKL/RANK system on ovariectomy-induced bone loss rat
por: Seo, Il-bok, et al.
Publicado: (2020)

Serum levels of RANKL and OPG, and the RANKL/OPG ratio in bisphosphonate-related osteonecrosis of the jaw: Are they useful biomarkers for the advanced stages of osteonecrosis?
por: Bagan, Leticia, et al.
Publicado: (2017)

"Single nucleotide polymorphisms of the OPG/RANKL system genes in primary hyperparathyroidism and their relationship with bone mineral density"
por: Piedra, María, et al.
Publicado: (2011)

Acupotomy Contributes to Suppressing Subchondral Bone Resorption in KOA Rabbits by Regulating the OPG/RANKL Signaling Pathway
por: Wang, Tong, et al.
Publicado: (2021)

Influence of DNA methylation on the expression of OPG/RANKL in primary osteoporosis
por: Wang, Peng, et al.
Publicado: (2018)

Effects of TGF-β1 on OPG/RANKL Expression of Cementoblasts and Osteoblasts Are Similar without Stress but Different with Mechanical Compressive Stress
por: Yang, Xianrui, et al.
Publicado: (2015)

Beyond Antibodies: B Cells and the OPG/RANK-RANKL Pathway in Health, Non-HIV Disease and HIV-Induced Bone Loss
por: Titanji, Kehmia
Publicado: (2017)

Bovine Milk Extracellular Vesicles Are Osteoprotective by Increasing Osteocyte Numbers and Targeting RANKL/OPG System in Experimental Models of Bone Loss
por: Oliveira, Marina C., et al.
Publicado: (2020)

The Effect of RANKL/OPG Balance on Reducing Implant Complications
por: Kapasa, Elizabeth R., et al.
Publicado: (2017)

Targeting the RANKL/RANK/OPG Axis for Cancer Therapy
por: Ming, Jie, et al.
Publicado: (2020)

Circulatory Levels of RANKL, OPG, and Oxidative Stress Markers in Postmenopausal Women With Normal or Low Bone Mineral Density
por: Azizieh, Fawaz Y, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_rmbh75t5buv21g2ctr403iqc1k