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On TCR binding predictors failing to generalize to unseen peptides

Several recent studies investigate TCR-peptide/-pMHC binding prediction using machine learning or deep learning approaches. Many of these methods achieve impressive results on test sets, which include peptide sequences that are also included in the training set. In this work, we investigate how stat...

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Detalles Bibliográficos
Autores principales: Grazioli, Filippo, Mösch, Anja, Machart, Pierre, Li, Kai, Alqassem, Israa, O’Donnell, Timothy J., Min, Martin Renqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9634250/
https://www.ncbi.nlm.nih.gov/pubmed/36341448
http://dx.doi.org/10.3389/fimmu.2022.1014256