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On TCR binding predictors failing to generalize to unseen peptides
Several recent studies investigate TCR-peptide/-pMHC binding prediction using machine learning or deep learning approaches. Many of these methods achieve impressive results on test sets, which include peptide sequences that are also included in the training set. In this work, we investigate how stat...
Autores principales: | Grazioli, Filippo, Mösch, Anja, Machart, Pierre, Li, Kai, Alqassem, Israa, O’Donnell, Timothy J., Min, Martin Renqiang |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9634250/ https://www.ncbi.nlm.nih.gov/pubmed/36341448 http://dx.doi.org/10.3389/fimmu.2022.1014256 |
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