Therapeutic potential of topical administration of acriflavine against hypoxia-inducible factors for corneal fibrosis

Transdifferentiation of keratocytes into fibroblasts or further into myofibroblasts, which produced denser and more disorganized extracellular matrix, is the major cause of corneal fibrosis and scarring, leading to corneal blindness. TGF-β1 is the critical cytokine for the myofibroblast’s transdiffe...

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Detalles Bibliográficos
Autores principales: Zhu, Shuyan, Shan, Huimin, Li, Jianqiao, Pan, Lijie, Wang, Shudan, Zhu, Jing, Guo, Hui, Mi, Fenghua, Wu, Xinyi, Yin, Jia, Pang, Kunpeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9634531/
https://www.ncbi.nlm.nih.gov/pubmed/36339559
http://dx.doi.org/10.3389/fphar.2022.996635

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9634531/
https://www.ncbi.nlm.nih.gov/pubmed/36339559
http://dx.doi.org/10.3389/fphar.2022.996635

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