Recycling Upstream Redox Enzymes Expands the Regioselectivity of Cycloaddition in Pseudo-Aspidosperma Alkaloid Biosynthesis

[Image: see text] Nature uses cycloaddition reactions to generate complex natural product scaffolds. Dehydrosecodine is a highly reactive biosynthetic intermediate that undergoes cycloaddition to generate several alkaloid scaffolds that are the precursors to pharmacologically important compounds suc...

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Detalles Bibliográficos
Autores principales: Kamileen, Mohamed O., DeMars, Matthew D., Hong, Benke, Nakamura, Yoko, Paetz, Christian, Lichman, Benjamin R., Sonawane, Prashant D., Caputi, Lorenzo, O’Connor, Sarah E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9634793/
https://www.ncbi.nlm.nih.gov/pubmed/36240425
http://dx.doi.org/10.1021/jacs.2c08107

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9634793/
https://www.ncbi.nlm.nih.gov/pubmed/36240425
http://dx.doi.org/10.1021/jacs.2c08107

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