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α(1) Proline 277 Residues Regulate GABA(A)R Gating through M2-M3 Loop Interaction in the Interface Region

[Image: see text] Cys-loop receptors are a superfamily of transmembrane, pentameric receptors that play a crucial role in mammalian CNS signaling. Physiological activation of these receptors is typically initiated by neurotransmitter binding to the orthosteric binding site, located at the extracellu...

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Detalles Bibliográficos
Autores principales: Kaczor, Przemyslaw T., Michałowski, Michał A., Mozrzymas, Jerzy W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9634794/
https://www.ncbi.nlm.nih.gov/pubmed/36219829
http://dx.doi.org/10.1021/acschemneuro.2c00401